POS0217 ALL-CAUSE AND CAUSE SPECIFIC MORTALITY AMONG PATIENTS WITH BEHCET’S DISEASE VERSUS GENERAL POPULATION

Background Behcet’s disease (BD) is a systemic vasculitis with multiorgan involvement. Objectives To compare the risk of all-cause and cause specific mortality among patients BD compared to general population Methods Using 2002-2017 Korea National Health Insurance database, we conducted cohort study matched on age sex at 1:5 ratio. The primary outcome was death any cause, secondary outcomes were cause-specific for top 5 causes death. Cox proportional hazards models estimated hazard ratios (HRs) 95% confidence intervals (CIs), comparing versus population. Results PS-matched (mean 42.1 years; 32.0% male) included 32288 161440 controls. During mean follow-up 9.6 years, 2214 deaths occurred. HR [95%] 10.6 [9.6-11.6]. Top derived from malignancy, cardiovascular disease, infection, respiratory injury: these 8.5 [7.2-10.1], 10.8 [8.6-13.6], 14.6 [8.1-26.3], 12.0 [8.5-17.0], 8.0 [5.0-13.0], respectively. Conclusion This population-based warns exceptionally heavy burden showing approximately 10 times higher In line this, also significantly patients, Disclosure Interests None declared